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KMID : 0377619620020050539
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Korean Jungang Medical Journal
1962 Volume.2 No. 5 p.539 ~ p.546
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Studies on Magnesium and Sodium Metabolism in Cirrhosis of the Liver
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Abstract
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A low serum magnesium concentration is often found in patients with chronic alcoholism and is associated with symptoms of hypomagnesemia including tremor, non-clonic muscular irritability and mental clouding. It is apparent that many of these alcoholic patients have cirrhosis of the liver, and a decrease of serum magnesium content in this disease also has been demonstrated. Magnesium balance studies in patients with chronic alcoholism with symptoms of hypomagnesmia proved markedly positive, indicating a total body magnesium deficiency. However, the overall frequency of coexisting cirrhosis of the liver was not indicated.
Determination of serum magnesium content of 20 cirrhotic patients showed the average of 1.63 ± 0.25 mEq/L in contrast to the average of 1.97 ± 0.28 mEq/L in 16 healthy people, reconfirming the occurrence of hypomagnesemia in cirrhosis of the liver.
Magnesium, potassium, phosphorous and nitrogen balance studies in 5 cirrhotic patients were performed for the purpose of detecting the status of total body magnesium and its relationship to other elements. All of the 5 patients showed moderate positive balance indicating total body deficiency of magnesium. The degree of positive magnesium balance was less striking than in patients with chronic alcoholism with tremor or delirium. Potassium and phosphorous also showed general pattern of positive balance, indicating some biochemical relationship between magnesium, potassium and phosphorous.
Magnesium and ATP contents of liver and ´muscle were determined periodically in the rats who were given daily 2cc per 100g body weight of 33% ethanol over 85 days. While the magnesium contents of liver and muscle of the rats thus treated did not show any significant changes during this period, ATP contents of liver and muscle of these rats decreased continuously with increased days of ethanol ingestion.
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